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目的 :探讨IL 8在喉癌及癌边缘组织中的表达及其与喉癌生物学行为的关系。方法 :采用免疫组化SABC方法对 35例原发喉癌及癌边缘 1.0cm组织中的IL 8进行检测。结果 :喉癌组中 2 4例阳性 (6 8.6 % ) ,癌旁组中 15例阳性 (42 .9% ) ,喉癌组与癌旁组阳性率之间差异显著 (P <0 .0 5 ) ;肿瘤发生部位、分化程度及是否有淋巴结转移差异不显著。结论 :提示IL 8在喉癌中可能起着一定的作用 ;其在喉癌中的高表达可能与患者的病程及免疫状态有关。
Objective: To investigate the expression of IL-8 in laryngeal carcinoma and its margins and its relationship with the biological behavior of laryngeal carcinoma. Methods: Immunohistochemical SABC method was used to detect IL 8 in 35 cases of primary laryngeal cancer and 1.0 cm of cancer margin. Results: Twenty-four cases were positive in laryngeal cancer group (8.6%), 15 cases in adjacent non-cancerous group (42.9%), and the difference between positive rate in laryngeal carcinoma group and adjacent non-cancerous group was significant (P <0.05) ); Tumor location, differentiation and lymph node metastasis were not significantly different. Conclusion: It is suggested that IL 8 may play a role in laryngeal carcinoma. The high expression of IL 8 in laryngeal carcinoma may be related to the course of disease and immune status.