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钙通道阻滞剂异搏停的常见副作用是引起便秘,但机理不清。作者采用安慰剂双盲对照和随机交叉比较的方法,前瞻性地定量研究了该药对消化道传输的影响。材料和方法:研究对象为15名健康男性。受试者每日口服异搏停(240mg)或安慰剂1次,连续5天。第1次服药48小时后检测血中异搏停及其代谢产物去甲基异搏停浓度,然后进标准固体餐并饮水350ml(含~(111)In标记的DTPA 250μCi)。取不同体位进行动态闪烁扫描。胃及远段回肠的闪烁图根据时间-放射强度曲线进行分析,示踪物达结肠的位置按几何中点法加以判定。间隔两周后,受试者改换药物进行第二轮试验。结果:异搏停组有4人(27％)、对照组有1人(7％)发生副反应,包括腹胀、口干和腹痛。排便次数、性状及排便难易程度在两组间无显著差异,但前者与
Common side effects of calcium channel blockers during stroke are constipation, but the mechanism is unclear. The authors used placebo double-blind control and randomized cross comparison method, a prospective quantitative study of the drug on the gastrointestinal transmission. MATERIALS AND METHODS: The subjects were 15 healthy males. Subjects were treated with verapamil (240 mg) or placebo once daily for 5 consecutive days. 48 hours after the first dose of blood test for verapamil and its metabolites to methyl prednisolone concentration, and then into the standard solid meal and drinking 350ml (~ (111) In labeled DTPA 250μCi). Take different positions for dynamic scintigraphy. Scintigraphy of the stomach and distal ileum was analyzed according to the time-radiation intensity curve, and the location of the tracer was measured by the geometric mid-point method. After an interval of two weeks, the subject changed medications for a second round of testing. RESULTS: Four patients (27%) in the verapamil group and one (7%) in the control group developed side effects including bloating, dry mouth and abdominal pain. There was no significant difference in the number of defecations, traits and defecation ease between the two groups, but the former was similar to the latter