Sematilide为Ⅲ类抗心律失常药。14例慢性频发室性心律失常患者,静滴本品0.15～1.5mg/kg(15分钟滴完)。结果发现,本品消除半减期3.6±0.8(2.3～5.5)小时,77±13%以原形随尿排出,肾廓清率每分钟195±67ml,稳态分布容积78±18 L_o滴注后10～15分钟,QTc间期延长达峰值,并与剂量、血浓度相关。PR间期、QRS波群无明显变化。当血浆浓度相当 Sematilide is Class III anti-arrhythmic drug. 14 cases of patients with chronic ventricular arrhythmias, intravenous 0.15 ~ 1.5mg / kg of this product (15 minutes drip End). The results showed that this product to eliminate the half-period of 3.6 ± 0.8 (2.3 to 5.5) hours, 77 ± 13% of the prototype with the urine excretion of renal clearance rate of 195 ± 67ml per minute, steady-state volume of 78 ± 18 L_o after infusion of 10 ~ 15 minutes, QTc interval extended up to the peak, and dose, blood concentration related. PR interval, QRS complex no significant change. When the plasma concentration is equivalent