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目的探讨甲型H1N1流感肺炎患儿的肺功能变化及其在临床诊断和治疗评估中的意义。方法测定53例甲型H1N1流感肺炎患儿(A组)潮气呼吸肺功能,并与87例同年龄段健康儿童(B组)对照。结果 A组潮气流速-容量环变窄,呼气曲线升枝陡峭,高峰提前,降枝呈波谷样凹陷。与B组比较,A组通气功能指标反映呼气功能障碍,尤其1个月~3岁年龄组患儿(P<0.05)。结论甲型H1N1流感肺炎患儿其急性期肺功能改变主要表现为气道阻塞性通气功能障碍;潮气呼吸肺功能测定可为甲型H1N1流感肺炎患儿评判病情程度及预后评估提供客观依据。
Objective To investigate the changes of lung function in children with influenza A (H1N1) pneumonia and its significance in the evaluation of clinical diagnosis and treatment. Methods Totally 53 children with influenza A (H1N1) pneumonia were enrolled in this study. The lung function was compared with 87 healthy children (Group B) of the same age group. Results In group A, the tidal flow velocity-volume ring became narrower, the expiratory curve rose steeply, the peak appeared ahead, and the descending branch showed wave-valley depression. Compared with group B, the ventilatory function index of group A reflected expiratory dysfunction, especially in 1 month to 3 years old group (P <0.05). Conclusions The changes of pulmonary function in children with influenza A (H1N1) pneumonia during the acute phase are mainly manifested as airway obstructive ventilatory dysfunction. Tidal breathing pulmonary function test may provide an objective basis for evaluating the severity and prognosis of children with influenza A (H1N1) pneumonia.