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利用链脲佐菌素（ＳＴＺ）引起的大鼠糖尿病性实验性白内障模型，观察小檗胺对晶状体上皮细胞ＤＮＡ损伤、修复及致障过程的影响．发现ＳＴＺ对照组在腹腔注射ＳＴＺ后３～４ｄ开始出现有显著意义的ＤＮＡ单链断裂（ｓｉｎｇｌｅｓｔｒａｎｄｂｒｅａｋｓ，ＳＳＢ），并持续存在于发病全程直至晶状体完全混浊．而在注射ＳＴＺ后１２ｈ再腹腔注射３．４８ｍｇ／ｋｇ体重，１．７４ｍｇ／ｋｇ体重小檗胺后，一周后才出现有显著意义的ＳＳＢ．３．４８ｍｇ／ｋｇ体重组在５周后白内障形成率明显低于ＳＴＺ组的同时，ＳＳＢ也恢复到对照水平，而１．７４ｍｇ／ｋｇ体重组第７周才恢复到对照水平．提示抗氧化药物小檗胺能在一定程度上阻止白内障发生过程中的ＤＮＡ损伤．
The streptozotocin (STZ) -induced diabetic experimental cataract model was used to observe the effects of berbamine on DNA damage, repair and the process of lens epithelial cell damage. Found that STZ control group began to have significant single DNA strand breaks (SSB) 3 ~ 4d after intraperitoneal injection of STZ, and persisted in the whole process until the lens was completely cloudy. However, after injecting STZ 12h and then injected intraperitoneally 3.48mg / kg body weight, 1.74mg / kg body weight berbamine, a week after the significant SSB. The rate of cataract formation in 3.48mg / kg body weight group was significantly lower than that in STZ group after 5 weeks, while the SSB also returned to the control level, while the control group returned to the control level at 7th week in 1.74mg / kg body weight group. Tip antioxidant berbamine to a certain extent, prevent DNA damage during cataract.