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本文报道1974年4月至1981年12月中山医学院肝癌研究室对原发性肝癌102例血清γ-谷氨酰转肽酶(γ-GT)的活性研究,并测定健康人33例和非肝癌癌症病人30例的γ—GT活性作为对照。原发性肝癌和非肝癌癌症病人均行手术治疗,术中探查肝脏,以病理确诊。结果,γ-GT是诊断原发性肝癌的良好依据,85.3％原发性肝癌病人γ-GT活性升高>40U％,并可为肝癌术前的良好参数,术前γ-GT越高,切除机会越小,特别γ-GT>200U％者,即使能手术切除,亦难以度过肝功能衰竭之难关,若γ-GT<40U％者,手术切除机会较高;若γ-GT在正常值内(<40单位/100ml血清),或术后降至正常者,预后良好;反之,γ-GT值升高或术后再升高者,其预后差。因此,结合临床及其他检查(甲胎蛋白检测等),γ-GT可作为肝癌的诊断、手术估价与疗效评价的良好肿瘤标记。
This paper reports on the activity of serum γ-glutamyl transpeptidase (γ-GT) in 102 patients with primary liver cancer from April 1974 to December 1981 in the Hepatocellular Research Laboratory of Zhongshan Medical College. The gamma-GT activity of 30 cases of liver cancer patients was used as a control. Both primary liver cancer patients and non-liver cancer patients were treated with surgery. The liver was explored during the operation and confirmed by pathology. Results, γ-GT is a good basis for the diagnosis of primary liver cancer, 85.3% of patients with primary liver cancer γ-GT activity increased> 40U%, and can be good parameters for preoperative liver cancer, the higher the preoperative γ-GT, The smaller the chance of removal, especially γ-GT>200U%, even if it can be surgically removed, it is difficult to overcome the difficulties of liver failure, if γ-GT <40U%, the chance of surgical resection is higher; if γ-GT is normal Within the value (<40 units/100ml serum), or postoperatively reduced to normal, the prognosis is good; conversely, if the γ-GT value is elevated or increased after surgery, the prognosis is poor. Therefore, combined with clinical and other tests (alpha-fetoprotein testing, etc.), γ-GT can be used as a good tumor marker for diagnosis, surgical evaluation and efficacy evaluation of liver cancer.