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目的探讨分析前列腺癌患者淋巴细胞亚群的变化与意义。方法对157例前列腺癌患者进行全身核素骨显像,前列腺癌患者和50例健康对照者采用流式细胞术检测外周血淋巴细胞亚群,采用电化学发光免疫分析法测血清总前列腺特异抗原(T-PSA)和游离前列腺特异抗原(F-PSA)的水平。结果前列腺癌骨转移III、IV级患者与I、II级患者、对照组相比,CD3+T淋巴细胞数降低,T-PSA、F-PSA水平升高,而CD4/CD8比值和F-PSA/TPSA水平逐级降低,差异均有统计学意义(P<0.05)。结论前列腺癌骨转移严重患者机体细胞免疫功能明显降低,监测细胞免疫功能,尤其是CD4/CD8比值对前列腺癌患者的治疗和预后有重要临床价值。
Objective To investigate the changes and significance of lymphocyte subsets in patients with prostate cancer. Methods Whole body radionuclide bone imaging was performed in 157 patients with prostate cancer. The peripheral blood lymphocyte subsets were detected by flow cytometry in prostate cancer patients and 50 healthy controls. The serum total prostate specific antigen (T-PSA) and free prostate-specific antigen (F-PSA). Results The numbers of CD3 + T lymphocytes, T-PSA and F-PSA in patients with grade III and IV of prostate cancer with bone metastasis were significantly higher than those in patients with grade I and II, and the ratio of CD4 / CD8 and F-PSA / TPSA levels decreased step by step, the differences were statistically significant (P <0.05). Conclusion The cellular immune function of patients with severe bone metastasis of prostate cancer is significantly reduced. Monitoring cellular immune function, especially CD4 / CD8 ratio, has important clinical value in the treatment and prognosis of patients with prostate cancer.