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直肠癌术后局部复发是直肠癌研究中的重要课题之一,据统计,约半数直肠癌病人死于术后肿瘤局部复发。对14例可切除的直肠癌病人行术中盆腔内高温化疗(IOPHC),并与12例直肠癌手术病人对照(对照组)。方法:当直肠癌切除加扩大淋巴结清扫术后,即在盆腔内注满温生理盐水,内含MMC40μg/ml。然后将自行设计的加热器放入加热,温度控制在45.5±0.6℃,持续90分钟,IOPHC后,食管内平均温度为37.2±0.8℃(<38.6℃)。在IOPHC中测定盆腔灌洗液及血中MMC浓度,并在术中、术后分别取盆腔灌洗液及引流液做肿瘤细胞学检查。
Local recurrence of rectal cancer is one of the important topics in the study of rectal cancer. According to statistics, about half of rectal cancer patients die after local recurrence of the tumor. Intraoperative pelvic hyperthermia (IOPHC) was performed on 14 patients with resectable rectal cancer and compared with 12 rectal cancer patients (control group). Methods: When the resection of rectal cancer plus enlarged lymph node dissection, the pelvic cavity was filled with warm saline, containing MMC40μg/ml. The self-designed heater was then placed in a heated, controlled temperature of 45.5 ± 0.6°C for 90 minutes. After an IOPHC, the mean temperature in the esophagus was 37.2 ± 0.8°C (<38.6°C). The pelvic lavage fluid and blood MMC concentrations were measured in IOPHC, and pelvic lavage fluid and drainage fluid were taken for cytological examination during and after surgery.