合成了10个新的铂络合物和5个已知的铂络合物,对6个铂络合物进行了小鼠S_(180)肉瘤的抗肿瘤活性试验,结果表明:6个铂络合物在所用剂量条件下均有较高的抗肿瘤活性,其抑瘤率T/C为15％至35％,与母体化合物顺铂比较,水溶性较高,毒性较低。适当改变铂络合物的化学结构,在其中引入某些亲水性基团,有利于铂络合物水溶性增加,毒性降低,并保持较高的抗肿瘤活性。 Ten new platinum complexes and five known platinum complexes were synthesized. Six platinum complexes were tested for the anti-tumor activity of mouse S 180 sarcoma. The results showed that: 6 platinum complexes The compound has high antitumor activity under the applied dose conditions, and the tumor inhibition rate T/C is 15% to 35%. Compared with the parent compound cisplatin, the compound has higher water solubility and lower toxicity. The proper modification of the chemical structure of the platinum complex, in which some hydrophilic groups are introduced, is beneficial to increase the water solubility of the platinum complex, reduce the toxicity, and maintain a high anti-tumor activity.