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甲型肝炎病毒(HAV)感染成人通常表现为黄疸和急性肝炎的症状,病程短,症状和体征数周内消退。本文作者报道了1例HAV感染后激发自身免疫性慢性活动性肝炎(CAH)的病例。 该病人女性,55岁,临床表现为右肋下疼痛、黄疸、尿黄、皮肤搔痒、疲劳厌食已2周。实验室检查有肝细胞损伤及血中测出IgM抗-HAV而确诊为急性甲型肝炎。该患者无饮酒、输血、静注毒品、接触肝炎和黄疸病人史,无特殊家族史。肝脾不肿大,血胆红素13.9mg/dl、碱性磷酸酶226 U/L、AST 1081U/L、血白蛋白3.7g/dL、IgG2070mg/dl,CT、B超检查正常,HBsAg、
Hepatitis A virus (HAV) infection usually presents as symptoms of jaundice and acute hepatitis, and the course of the disease is short and symptoms and signs subside within weeks. The authors reported a case of autoimmune chronic active hepatitis (CAH) that elicited one case of HAV infection. The patient, 55 years old, had clinical manifestations of right subcostal pain, jaundice, yellow urine, itchy skin, and anorexia nervosa for 2 weeks. Laboratory tests of liver cell injury and blood IgM anti-HAV was diagnosed as acute hepatitis A. The patient had no alcohol, blood transfusion, intravenous drugs, history of exposure to hepatitis and jaundice, and no special family history. Hepatosplenomegaly and hepatosplenomegaly did not enlarge, blood bilirubin 13.9mg / dl, alkaline phosphatase 226U / L, AST 1081U / L, serum albumin 3.7g / dL, IgG2070mg / dl,