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发展了一种新的超分子亚胺离子催化的策略.为了提高传统亚胺离子催化的效率并且提供一种新的不对称催化方法,最近发展了一种致力于活化亚胺离子的新催化概念,即超分子亚胺离子催化.为了扩展该策略的应用范围,在此进一步发展了该方法,使之拓展到可以同时对亚胺离子和亲核体进行双活化的超分子亚胺离子催化方法.这种新的方法可以显著提高催化剂的活性,使之前应用传统方法比较惰性的反应变得具有良好的反应性.报道的方法可以用于提高一些比较惰性反应的反应活性,也可以为设计一些新反应提供一种思路.
A new strategy for supramolecular imine ion catalysis has been developed.In order to increase the efficiency of traditional imine ion catalysis and to provide a new asymmetric catalysis approach a new catalytic concept dedicated to activating iminium ions has been developed , That is supramolecular imine ion catalysis.In order to expand the application scope of this strategy, this method is further developed here, which extends to a supramolecular imine ion catalysis method which can simultaneously activate imine ions and nucleophiles. This new method can significantly improve the activity of the catalyst, so that the previous application of traditional methods more inert reaction has become very good reactivity.The reported method can be used to improve some of the more inert reaction reactivity, but also for the design of some new The reaction provides a way of thinking.