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目的探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)合并亚临床甲状腺功能减退(subclinical hypothyroidism,SCH)的发病情况,及合并这两种内分泌疾病对妊娠结局的影响。方法选择2012年1月-12月在北京市通州区妇幼保健院分娩的孕妇,分为四组(GDM组、SCH组、GDM+SCH组及对照组),对四组的妊娠结局进行比较。结果妊娠合并SCH患者中GDM发生率达45%,GDM+SCH组的妊娠期高血压疾病、妊娠期蛋白尿、剖宫产率、早产、胎儿低体重高于其他组。结论临床工作中,应重视糖代谢异常孕妇甲状腺功能的筛查,以减少母儿并发症。
Objective To investigate the incidence of gestational diabetes mellitus (GDM) combined with subclinical hypothyroidism (SCH) and the effect of combining the two endocrine diseases on pregnancy outcome. Methods Pregnant women delivered in Tongzhou District Maternal and Child Health Hospital of Beijing from January to December 2012 were divided into four groups (GDM group, SCH group, GDM + SCH group and control group). Pregnancy outcomes of the four groups were compared. Results The incidence of GDM was 45% in pregnancy with SCH. The incidence of gestational hypertension, gestational proteinuria, cesarean section rate, premature birth and fetal low body weight in GDM + SCH group were higher than those in other groups. Conclusions In clinical work, we should pay attention to the screening of thyroid function in pregnant women with abnormal glucose metabolism to reduce the complications of maternal and child.