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目的:分析我院药品不良反应/事件(ADR/ADE)发生的特点及影响因素,促进临床用药安全。方法:对我院2006～2008年报告的182例ADR病例,按患者年龄、给药途径、药物类别、临床表现进行统计、分析和评价。结果:报告的182例中一般ADR为171例(93.96%),严重ADR为11例(占6.04%),主要临床表现为皮肤及附件(占45.60%),心血管系统(占13.74%),过敏样反应及过敏性休克(占9.89%)、消化系统(占7.69%);涉及ADR的药品有103种220例次,其中抗微生物药物106例次(占48.18%),中药注射剂45例次(占20.45%),给药方式以静脉滴注为主(占78.57%),其次为口服(占13.19%)。结论:做好ADR/ADE监测可促进合理用药,保证临床用药安全。
Objective: To analyze the characteristics and influencing factors of ADR / ADE in our hospital and to promote the safety of clinical medication. Methods: A total of 182 ADR cases reported in our hospital from 2006 to 2008 were statistically analyzed, analyzed and evaluated according to patient’s age, route of administration, drug category and clinical manifestations. RESULTS: Of the 182 reported cases, 171 (93.96%) had ADRs in general and 11 (6.04%) had serious ADRs. The main clinical manifestations were skin and appendages (45.60%), cardiovascular system (13.74%), Allergic-like reactions and anaphylactic shock (accounting for 9.89%), digestive system (accounting for 7.69%); there were 103 kinds of 220 kinds of drugs involving ADR, of which 106 cases were antimicrobial drugs (48.18%), 45 cases of Chinese medicine injection (Accounting for 20.45%). The main mode of administration was intravenous drip (78.57%), followed by oral (13.19%). Conclusion: Good ADR / ADE monitoring can promote the rational use of drugs to ensure the safety of clinical medication.