论文部分内容阅读
据估计,发展中国家和发达国家每年分别有1.6亿和150万痢疾患者。美国WalterReed陆军研究所Katz在北美志愿者中对2a型福氏志贺菌SC602株制备的减毒口服活疫苗进行了安全性与免疫原性测定。2a型福氏志贺菌SC602株是缺失icsA(virG)质粒毒力基因的减毒活疫苗株。在第1项门诊病人研
It is estimated that 160 million and 1.5 million people with dysentery each year develop in developing and developed countries respectively. Katz, a WalterReed Army Research Institute at the U.S. Army, conducted a safety and immunogenicity test of attenuated oral live vaccines prepared from the Shigella flexneri 2a strain SC602 in North American volunteers. Type 2a Shigella flexneri SC602 strain is an attenuated live vaccine strain lacking the virulence gene of icsA (virG) plasmid. In the first outpatient research