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文献报道巴比妥类药物对动物有致畸胎作用。为了解该类药物对母鼠的分娩和F1仔鼠生长发育的影响,作者选用巴比妥钠进行了围产期毒性研究。巴比妥钠为中国医药公司产品(批号890310),设50、500ppm组,MAPO阳性对照组,溶剂对照组。每组30只孕鼠,自孕期第15d经饮水给药至断乳止,各组给药时间均为28d。结果表明,给巴比妥钠后对孕鼠体重增长及分娩无明显影响,未见到对胎仔有致畸作用。给药组产死胎率为0.0%～1.6%,溶剂对照组0.5%,MAPO阳性对照组为5.0%。
The literature reports that barbiturates have teratogenic effects on animals. In order to understand the effects of these drugs on the delivery of mothers and the growth and development of F1 offspring, the authors selected sodium pentobarbital for perinatal toxicity studies. Sodium pentobarbital products for the Chinese pharmaceutical company (batch number 890310), set 50,500ppm group, MAPO positive control group, solvent control group. Each group of 30 pregnant rats, from the fifteenth day of pregnancy by drinking water to wease only, the time of administration for each group were 28d. The results showed that after giving sodium pentobarbital weight gain and delivery of pregnant rats had no significant effect, no teratogenic effects on the fetus. The rate of stillbirths in the administration group was 0.0% -1.6%, that in the solvent control group was 0.5%, and that in the MAPO positive control group was 5.0%.