目的　研究胃癌组织中p5 3和P 糖蛋白表达的意义。方法　应用SP免疫组织化学的方法对 98例胃癌进行检测。结果　在 98例胃癌中 ,5 9.8%的 p5 3表达阳性 ,5 7.1%的P 糖蛋白表达阳性。p5 3和P 糖蛋白与胃癌的分化程度和生存期限有关 (P <0 .0 5 )。p5 3还与胃癌的浸润程度 ,淋巴结转移情况有关。P 糖蛋白表达阳性者 ,在 p5 3表达阳性组 ,明显高于 p5 3表达阴性组。 结论　联合检测 p5 3蛋白和P 糖蛋白对胃癌的诊断、治疗和预后有重要意义 Objective To study the significance of p53 and P glycoprotein expression in gastric cancer. Methods 98 cases of gastric cancer were detected by SP immunohistochemical method. Results In 98 cases of gastric cancer, 5 9.8% of p53 was positive and 5 7.1% of P glycoprotein was positive. The p53 and P glycoproteins were associated with the degree of differentiation and duration of survival of gastric cancer (P < 0.05). P53 is also related to the extent of gastric cancer infiltration and lymph node metastasis. Positive P-glycoprotein expression was significantly higher in the p53-positive group than in the p53-negative group. Conclusion Combined detection of p53 protein and P glycoprotein is important for the diagnosis, treatment and prognosis of gastric cancer