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NIH 小鼠感染日本血吸虫尾蚴后35天,用吡喹酮300mg/kg 灌胃治疗,分别于用药后0.5、1、2、4、8、16和32小时经鼠门静脉收集成虫制备扫描电镜标本。用药后0.5～2小时虫体皮层已出现显著损伤,扫描电镜下观察到褶嵴肿胀、融合及类蜂窝样改变。4～8小时一些部位有小片状糜烂或溃破。16～32小时出现较广泛的大片区域坏死和剥脱现象。多于用药后0.5～4小时,虫体皮层的凹陷、洞穴或类蜂样损伤处有淋巴细胞、白细胞和红细胞粘附。
NIH mice infected with Schistosoma japonicum cercariae 35 days after treatment with praziquantel 300mg / kg gavage, were collected at 0.5, 1, 2, 4, 8, 16 and 32 hours after administration of adult mouse via the portal vein to prepare scanning electron microscopy specimens. After 0.5 to 2 hours after treatment, significant damage has occurred in the cortex of the parasites, and the changes of pleural crest swelling, fusion and honeycomb-like changes were observed under a scanning electron microscope. 4 to 8 hours some parts of a small piece of erosion or ulceration. 16 ~ 32 hours a wide range of large areas of necrosis and exfoliation. More than 0.5 to 4 hours after treatment, the worm cortex depression, cave or class bee-like damage at the lymphocytes, white blood cells and red blood cell adhesion.