胆囊切除术是临床上广为开展的一项手术,近年来有文献报告胆囊切除术后的人群患大肠癌的危险性明显增高,引起人们的关注,本文就此问题进行简要综述。一、胆汁酸与大肠癌近20年来,动物实验和流行病学的资料都提示胆汁酸及其代谢产物对大肠癌的发生和发展起着重要作用。包括裸鼠在内的动物实验模型已确定了胆汁酸的致癌潜力。皮下滴注脱氧胆酸(其化学结构似致癌剂多环碳水化合物)能直接 Cholecystectomy is a widely performed clinical procedure. In recent years, there have been reports in the literature that the risk of colorectal cancer in people with post-cholecystectomy has increased significantly. This has caused people’s concern. This article briefly reviews this issue. First, bile acid and colorectal cancer in the past 20 years, animal experiments and epidemiological data suggest that bile acids and their metabolites play an important role in the occurrence and development of colorectal cancer. Animal experimental models including nude mice have identified the carcinogenic potential of bile acids. Subcutaneous infusion of deoxycholic acid (its chemical structure resembles carcinogenic polycyclic carbohydrates) can be directly