1924年,Warburg 等报道癌组织的需氧酵解速率较正常组织增快。1954年,Greenstein总结了不同来源肿瘤酶表型的相似性,并提出了“趋同理论(convergence theory)”。1964年,Potter 又提出“酶丢失假说(deletion theory)”,即癌细胞和正常细胞不同,它不能合成所需要的酶或辅酶,或者调节酶活性的机制存在缺陷。1966—1967年,Weber 和 Lea 在比较生长速率 In 1924, Warburg et al. reported that the rate of aerobic glycolysis in cancer tissues increased faster than normal tissue. In 1954, Greenstein summarized the similarities of tumor phenotypes from different sources and proposed the “convergence theory.” In 1964, Potter proposed the “deletion theory” that cancer cells are different from normal cells in that they cannot synthesize the required enzymes or coenzymes, or that there is a defect in the mechanisms that regulate enzyme activity. From 1966 to 1967, Weber and Lea are comparing growth rates