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目的:观察早期口服布洛芬治疗极低体质量儿动脉导管未闭(PDA)的疗效及安全性。方法:将45例极低出生体质量儿随机分成早期治疗组25例,生后早期(日龄2～3d)经心脏彩超证实PDA,即予以口服布洛芬混悬液;对照组20例,因临床出现PDA征象而经心脏彩超证实有PDA存在后,再予以布洛芬混悬液治疗。观察两组疗效及不良反应。结果:早期治疗组PDA关闭23例(91.3%),对照组关闭15例(75.0%),两组比较差异无统计学意义(P>0.05);两组血肌酐、血小板、坏死性小肠结肠炎(NEC)、脑室内出血(IVH)情况比较差异无统计学意义(P>0.05);对照组喂养不耐受发生率较高(P<0.05);早期治疗组机械通气时间较短、住院时间较短(P<0.05)。结论:早期口服布洛芬治疗极低出生体质量儿PDA疗效确切且较安全,生后3d内早期应用有益于减少机械通气时间、缩短住院时间。
Objective: To observe the efficacy and safety of early oral ibuprofen in the treatment of very low birth weight children with patent ductus arteriosus (PDA). Methods: Forty-five children with very low birth weight were randomly divided into early treatment group (n = 25) and early PDA (day 2 ~ 3d). PDA was orally administered by echocardiography. Oral ibuprofen suspension was given. Due to clinical signs of PDA and confirmed by PDA after the presence of PDA, and then treated with ibuprofen suspension. The curative effect and adverse reaction of two groups were observed. Results: There were 23 cases (91.3%) in the early treatment group and 15 cases (75.0%) in the control group. There was no significant difference between the two groups (P> 0.05). Serum creatinine, platelet, necrotizing enterocolitis (P> 0.05); the incidence of feeding intolerance in the control group was higher (P <0.05); the duration of mechanical ventilation in the early treatment group was shorter and the length of hospital stay was longer Short (P <0.05). Conclusion: Early oral ibuprofen treatment of very low birth weight children with PDA is effective and safe, early application of 3d after birth is beneficial to reduce the mechanical ventilation time and shorten the hospitalization time.