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The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method.Rats performed willed-movement(climbing a ladder or wall in a box) when induced by food and water.Results revealed that Longa scores of neurological deficits significantly de-creased in the willed-movement group at 15 days after reperfusion,while expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion.Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43.
The present study established rat models of middle cerebral artery ischemia / reperfusion using the thread method. Rats performed willed-movement (climbing a ladder or wall in a box) when induced by food and water. Results revealed that Longa scores of neurological deficits significantly de -creased in the willed-movement group at 15 days after reperfusion, while expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion. Results indicated that willed-movement ameliorated neurological deficits by increasing expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43.