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目的:了解我院药品不良反应(ADR)发生情况及引发因素,为临床合理用药提供参考,提高ADR监测工作质量。方法:随机抽取我院2007年1月～2009年8月上报的药品不良反应/事件(AOR/ADE)报告200例进行统计分析。结果:200例中一般ADR 194例(97.00%);性别、年龄与ADR的发生无明显相关;院内门诊ADR39例;抗菌药引发的ADR最多(125例,62.50%),其次为中成药(20例,10.00%);静脉用药引发ADR 166例(83.00%);临床表现以皮肤及其附件最常见(95例,47.5%);无死亡及后遗症报告;医师上报169例(84.50%)。结论:加强ADR监测工作,可促进临床合理用药,保障患者用药安全,提高ADR报告和监测工作质量。
OBJECTIVE: To understand the occurrence and triggering factors of Adverse Drug Reactions (ADR) in our hospital so as to provide references for clinical rational drug use and to improve the quality of ADR monitoring. Methods: We randomly selected 200 cases of AOR / ADE reported in our hospital from January 2007 to August 2009 for statistical analysis. Results: There were 194 cases (97.00%) of common ADR in 200 cases. There was no significant correlation between gender and age with the occurrence of ADR. There were 39 cases of inpatient ADR in hospital and the most ADR caused by antimicrobial agent was 125 cases (62.50%), (95%, 47.5%); no death and sequelae were reported; and 169 cases (84.50%) were reported by physicians. Conclusion: To strengthen the monitoring of ADR can promote clinical rational use of drugs, ensure the safety of patients and improve the quality of ADR reporting and monitoring.