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通过观察参麦注射液对肥厚心肌电活动的影响,初步探讨其保护心脏的电生理机制。采用横主动脉弓部分狭窄建立压力超负荷性大鼠心肌肥厚模型,采用玻璃微电极技术记录左心室乳头肌细胞动作电位(AP)及自发的后除极(包括早后除极EAD、迟后除极DAD)。结果显示与假手术组相比,模型组大鼠左心室乳头肌动作电位时程90%复极化时间(APD90)明显延长,参麦注射液组和胺碘酮组无显著性变化;模型组可见明显的EAD和DAD,假手术组未见EAD和DAD的出现,参麦注射液组和胺碘酮组发生率明显降低。结果提示,参麦注射液通过改善肥厚大鼠心肌异常的电生理活动,能够预防其心律失常的发生。
By observing the effect of Shenmai injection on hypertropic cardiomyocytes, the electrophysiological mechanisms of protecting heart were preliminarily discussed. The model of myocardial hypertrophy was established by partial transverse aortic arch stenosis. The action potential of left ventricular papillary muscle cells (AP) and spontaneous post-depolarization (including early depolarization EAD, late depolarization DAD). The results showed that compared with the sham operation group, the APD90 of the left ventricular papillary muscle in the model group was significantly prolonged, and there was no significant change in the Shenmai injection group and the amiodarone group. The model group Visible EAD and DAD, sham-operated group did not appear EAD and DAD, Shenmai injection group and amiodarone group significantly reduced the incidence. The results suggest that Shenmai injection can prevent the occurrence of arrhythmia by improving the abnormal electrophysiological activity of cardiac hypertrophy in rats.