论文部分内容阅读
目的:利用羊水细胞染色体核型分析对高龄孕妇进行产前诊断。方法:对910例孕16～27周高龄孕妇进行羊膜腔穿刺抽取羊水细胞培养,制备染色体并分析染色体核型。结果:910例高龄孕妇,羊水培养成功891例,成功率为97.91%。5例术后流产,流产率为0.55%。检出43例异常核型,其中常染色体数目异常24例,性染色体数目异常6例,嵌合体2例,结构异常11例。结论:羊水细胞染色体核型分析高龄孕妇产前诊断是安全、有效且必要的。
Objective: To make prenatal diagnosis of pregnant women by amniotic fluid cell karyotype analysis. Methods: 910 cases of pregnant women aged from 16 to 27 weeks of age were amniocentesis amniotic fluid cell culture, chromosome preparation and analysis of chromosome karyotype. Results: A total of 910 pregnant women and amniotic fluid were successfully cultured, with a success rate of 97.91%. 5 cases of postoperative abortion, abortion rate was 0.55%. 43 cases of abnormal karyotype were detected, including 24 cases with an autosomal abnormality, 6 cases with abnormal sex chromosome number, 2 cases with chimerism and 11 cases with abnormal structure. Conclusion: The amniotic fluid cell karyotype analysis of prenatal diagnosis of pregnant women is safe, effective and necessary.