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目的 :探讨没食子儿茶素没食子酸脂 (EGCG)对肾缺血再灌注时细胞凋亡的抑制作用。方法 :建立大鼠肾缺血再灌注损伤的动物模型 ,对 Cr、BU N、一氧化氮 (NO)、Ca2 + - ATP酶活性进行测定并对肾细胞凋亡及组织病理进行观察。结果 :EGCG高剂量 (40 m g/ kg) Cr(17.89± 8.4 8) μm ol/ L、BUN (4.91± 2 .71) μmol/ L、NO (0 .38± 0 .17) μm ol/ g prot比空白对照组明显降低 (均 P <0 .0 1) ,Ca2 + - ATP酶 (0 .6 2± 0 .13) mm ol/ g prot· h- 1 比空白对照组明显升高 (P <0 .0 1) ,并且能有效抑制细胞凋亡的产生 ,且较维生素 C组作用更明显。结论 :EGCG能减轻肾缺血再灌注损伤 ,减少细胞凋亡的发生 ,其作用机制可能与降低细胞内的 Ca2 + 和 NO浓度有关。
Objective: To investigate the inhibitory effect of EGCG on renal cell apoptosis induced by renal ischemia-reperfusion. Methods: Animal models of renal ischemia / reperfusion injury were established in rats. The activities of Cr, BU N, NO and Ca2 + - ATPase were measured and the renal cell apoptosis and histopathology were observed. RESULTS: Compared with the control group, EGCG had a significantly higher Cr (17.89 ± 8.48) μmol / L, BUN (4.91 ± 2.71) μmol / L and NO (P <0.01) and Ca (superscript 2 +) - ATPase (0.62 ± 0.13) mm ol / g prot · h-1 were significantly higher than those in the blank control group (P < 0 .0 1), and can effectively inhibit the generation of apoptosis, and more obvious than vitamin C group. CONCLUSION: EGCG can reduce renal ischemia-reperfusion injury and reduce apoptosis, and its mechanism may be related to the decrease of intracellular concentrations of Ca2 + and NO.