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Arsenic trioxide(ATO)can induce cellular apoptosisand inhibit the activities of multiple myeloma(MM)cells in vitro,1 but how it works is not very clear.Recentstudies showed that ATO worked on the voltage-dependent potassium channel and L-type calcium channelin myocardial cells,but the effect of ATO on ionchannels of tumor cells was rarely reported.As thepotassium channel plays an important role in controllingcell proliferation,we studied the effects of ATO on thevoltage-dependent potassium current(Ikv)of thevoltage-dependent potassium channel in an MM cell line,and probed into the relationship between changes of theIkv caused by ATO and cell proliferation.
Arsenic trioxide (ATO) can induce cellular apoptosis and inhibit the activities of multiple myeloma (MM) cells in vitro, 1 but how it works is not very clear.Recent studies showed that ATO worked on the voltage-dependent potassium channel and L-type calcium channelin myocardial cells, but the effect of ATO on ion channels of tumor cells was rarely reported. As the potassium channel plays an important role in controlling cell proliferation, we studied the effects of ATO on the voltage-dependent potassium current (Ikv) of the voltage-dependent potassium channels in an MM cell line, and probed into the relationship between changes of the Ikv caused by ATO and cell proliferation.