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健康者及肾功损害的病人单剂或多剂量口服或静脉注射环丙氟哌酸的药动学已有研究,本文观察肝功损害病人与健康者口服环丙氟哌酸后的药动学以及病人合并使用其它药物如利尿药、H_2-阻滞剂对环丙氟哌酸药动学的影响。方法:19名肝功损害病人(男11名,女8名,平均年龄50岁),7名健康志愿者(男4名,女3名,平均年龄36岁)口服环丙氟哌酸500mg,测定血药浓度。按照肝功损害程度由轻到重将受试病人分为A(8名,轻度)、B(5名,中度)、C(6名,重度)三组。合并用药实验是将26名受试者分为合并使用利尿药
Pharmacokinetics of ciprofloxacin administered orally or intravenously to healthy and renal impairment patients have been studied. The pharmacokinetics of ciprofloxacin after oral administration of ciprofloxacin As well as the effect of combining other drugs such as diuretics and H_2-blockers on the pharmacokinetics of ciprofloxacin in patients. Methods: Nineteen patients with liver damage (11 males and 8 females, mean age 50 years) and 7 healthy volunteers (4 males and 3 females, mean age 36 years) were given oral ciprofloxacin 500 mg, Determination of plasma concentration. Patients were divided into three groups: A (8 mild), B (5 moderate), C (6 severe) according to the severity of liver damage. A combined medication trial divided 26 subjects into diuretics for combination use