目的观察急性心梗后不同时间溶栓与疗效的关系。方法对１９０例患者分为两组，治疗组用国产尿液酶２５万Ｕ／ｋｇ；对照组用极化液１００ｍｌ静滴。记录用药前，用药后即刻及３ｈ，８ｈ，１２ｈ心电图抬高的Ｓ－Ｔ段平方面积（ｍｍ２）。结果用药后３ｈＳ－Ｔ段下降水平明显，＞５０％，８ｈ内溶栓效果继续发挥作用。结论入院６ｈ内用药病死率低（９４％），给药时间延迟病死率明显递增。 Objective To observe the relationship between thrombolysis and curative effect in different time after acute myocardial infarction. Methods 190 patients were divided into two groups, the treatment group with domestic urine enzyme 250,000 U / kg; control group with 100ml intravenous infusion. Record before treatment, immediately after treatment and 3h, 8h, 12h ECG elevation S-T square area (mm2). Results 3h after treatment, the level of S-T decreased significantly,> 50%, 8h thrombolytic effect continue to play a role. Conclusions The mortality rate of drug use within 6 hours after admission is low (94%), and the delay in the administration time is obviously increased.