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疟原虫子孢子经传染蚊注入人体后,几分钟内侵入肝细胞,尔后几天内增殖为成千上万个能感染红细胞的裂殖子。尽管对子孢子和疟原虫的肝组织期有了一定认识,但仍不了解其到达肝脏并进入肝细胞的机制。最近的研究表明环子孢子蛋白(CS)可结合到肝细胞表面的硫酸乙酰肝素蛋白多糖(HSPGs)上。本文作者就受体与配体相互作用对于子孢子入侵的意义作了简要综述。 肝细胞被子孢子感染的速度及选择性提
Plasmodium sporozoites infect the human body by the infectious mosquito, invade the hepatocytes in minutes, and proliferate into tens of thousands of merozoites that can infect erythrocytes within a few days. Despite some knowledge of the liver tissue of sporozoites and Plasmodium, mechanisms for reaching the liver and entering hepatocytes are still unknown. Recent studies have shown that circumsporozoite protein (CS) binds to hepatic heparan sulfate proteoglycans (HSPGs) on the surface of hepatocytes. The authors review briefly the significance of receptor-ligand interactions for sporozoite invasion. The speed and selectivity of hepatocyte infection by sporozoites