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为防止脾切除后凶险感染(OPSI),常行各种保脾术,包括自体脾薄片移植,可能时联合接种。自体脾移植的难点是功能评价,找到合适的检查方法,来反映出不能为体内其它淋巴组织所能代替的脾特殊功能。已确认脾有两大主要功能,即作为大型吞噬细胞滤器和抗体主要的产生器官。脾能产生调理素,合成补体。对未调理化或调理化差的颗粒的吞噬作用尤其重要。在兔实验上,按体重计,脾这种吞噬能力为肝的60倍。这归功于脾独有的微脉管系统,其红髓索极大地减缓血流,使抗原和吞噬细胞的接触密切和延长,在无特异性配体一受体相互作用的情况下,吞噬
In order to prevent the risk of malignant infection after splenectomy (OPSI), often a variety of spleen preservation, including splenic autologous transplantation, when possible when the joint vaccination. Difficulties in autologous splenic transplantation are functional evaluation and finding suitable screening methods to reflect the special function of the spleen that can not be replaced by other lymphoid tissues in the body. It has been confirmed that the spleen has two major functions, that is, the major organ of production of large phagocyte filters and antibodies. Spleen can produce opsonins, synthetic complement. It is especially important for phagocytosis of unregulated or opsonized particles. In rabbit experiments, by weight, the phagocytosis of the spleen is 60 times that of the liver. This is attributed to the spleen’s unique microvasculature, whose red cord greatly slows blood flow, allowing the antigen and phagocyte contacts to be close and prolonged, phagocytosis in the absence of specific ligand-receptor interactions