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选择符合Poser(Ann Neurol1983;13:227)临床诊断标准的多发性硬化(MS)患者共21例,其中男6例,女15例。平均年龄31.8岁。这些MS患者中,处于稳定期的6例,复发期15例。对照组18例,为同期住院的神经官能症病人。所有患者初次腰穿术取脑脊液前,至少3月以上无激素治疗史。15例复发期MS于初次腰穿术后应用15～20mg地塞米松静注,14天后减量并行第二次腰穿术取CSF,每次腰穿术的同时经肘静脉取血。血浆和CSF生长抑素(SS)含量采用放射免疫法测定。结果复发期MS、CSF、SS含量显著低于对照组和稳定期组(P<0.01),稳定期MS、CSF、SS含量与对照组比较有下降趋势,但无显著性差异(P>
A total of 21 patients with multiple sclerosis (MS) were selected according to the clinical diagnostic criteria of Poser (Ann Neurol 1983; 13: 227), including 6 males and 15 females. The average age is 31.8 years old. Of these MS patients, 6 were in stable phase and 15 were relapsed. The control group of 18 patients for the same period hospitalized neurosis patients. All patients with lumbar puncture before taking cerebrospinal fluid, at least 3 months without hormone therapy history. 15 cases of relapse MS after initial lumbar surgery with dexamethasone intravenous injection of 15 ~ 20mg, 14 days after the reduction in parallel with the second lumbar puncture to take CSF, each lumbar puncture through the elbow venous blood. Plasma and CSF somatostatin (SS) levels were measured by radioimmunoassay. Results The levels of MS, CSF and SS in relapse stage were significantly lower than those in control group and stable stage (P <0.01). The content of MS, CSF and SS in stable stage showed a decreasing trend compared with control group, but no significant difference (P>