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目的:观察理肠汤合盐酸舍曲林片治疗腹泻型肠易激综合征的临床疗效。方法:将72例腹泻型肠易激综合征病人随机分为两组,治疗组37例,以自拟理肠汤(痛泻要方合金铃子散加味)同时口服盐酸舍曲林片50mg,每日晨起1次;对照组35例,单纯口服理肠汤。两组服药期间均停服其他药物,所有病例均给予心理疏导和饮食调整,疗程4周。结果:总有效率治疗组为86.5%,对照组为65.7%,两组比较,差异有显著性意义(P<0.05);两组治疗后主要症状积分均有明显改善,与治疗前比较,差异有显著性或非常显著性意义(P<0.05或P<0.01);除腹胀、排便不尽感外,治疗组与对照组治疗后比较,差异有显著性或非常显著性意义(P<0.05或P<0.01)。结论:理肠汤合盐酸舍曲林针对病因治以疏肝健脾、解郁安神,使患者身心逐渐进入一种良性循环状态,从而使病情得到明显改善。
Objective: To observe the clinical curative effect of treating the diarrhea-predominant irritable bowel syndrome (IBS) Methods: Seventy-two patients with diarrhea-predominant irritable bowel syndrome were randomly divided into two groups. The treatment group consisted of 37 patients. A total of 50 mg of sertraline hydrochloride tablets were given orally at the same time. 1 times daily morning; control group of 35 cases, simple oral administration of intestinal soup. Both groups stopped taking other drugs during their medication. All cases were given psychological counseling and dietary modification for 4 weeks. Results: The total effective rate was 86.5% in the treatment group and 65.7% in the control group, with significant difference between the two groups (P <0.05). The main symptom scores of both groups were significantly improved after treatment, (P <0.05 or P <0.01). In addition to abdominal distension and defecation, the difference between the treatment group and the control group after treatment was significant or very significant (P <0.05 or P <0.01) P <0.01). Conclusion: Ligusticum soup combined with sertraline hydrochloride for the etiology of Shuganjianpi, Jieyu soothe the nerves, so that patients gradually into a virtuous cycle of physical and mental state, so that the disease has been significantly improved.