患儿,男,4岁半,出生后发现头面部、双指,趾畸形,一岁时行左拇指侧、右小指侧多指切除术,随年龄增长,患儿智力低下,表情痴呆,动作幼稚,不会话,固执,不听劝导等,患儿足月顺产,其父左足趾第4、5趾、趾并趾畸形。其父母非近亲结婚,体检:发育不良,瘦小体型,头略尖,前额稍凸,前后囱门已闭合,颜面部轻度内凹、双睑裂较小,双外耳轮向前卷曲,鼻孔轻度外翻,平时呈张口口型、腭部呈高弓状,无腭裂,乳牙仅4个,不对称。双指、趾呈不对称性多指(或趾)、并指 Children, male, 4 years and a half, after birth found that the head and face, two fingers, toe deformity, one year old left thumb, right little finger multinuclear multiple finger surgery, with age, children with mental retardation, dementia, movements Childish, not talking, stubborn, do not listen to advice, etc. Children with full-term follow-up, his father left toe 4,5 toe, toe deformity. His parents were married to non-relatives, physical examination: poor development, thin body, slightly pointed, slightly convex forehead, before and after the hilar has closed, slightly concave face, double palpebral fissure smaller, double outer ear curl forward curl, nostril light Degree of valgus, was usually Zhang mouth type, the palate was bow-shaped, no cleft palate, deciduous teeth only 4, asymmetric. Two fingers, toes were asymmetric more fingers (or toe), and refers to