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作者以前的研究显示血管紧张素Ⅱ (AngⅡ )通过Ras -PKCzeta -MEK途径激活血管平滑肌细胞(VSMC)系裂素活化的蛋白激酶或细胞外信号调节激酶 (ERK1 /2 )。然而 ,这不能解释AngⅡ促进VSMC增生的作用可被PI3K的抑制剂Wortmannin所阻断
Previous studies by the authors showed that angiotensin II activates vascular smooth muscle cells (VSMCs) by the Ras-PKCzeta-MEK pathway, or mitochondria-activated protein kinase or extracellular signal-regulated kinase (ERK1 / 2). However, this does not explain that the effect of Ang II on VSMC proliferation can be blocked by PI3K inhibitor Wortmannin