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作者以前的研究显示血管紧张素Ⅱ (ＡｎｇⅡ )通过Ｒａｓ -ＰＫＣｚｅｔａ -ＭＥＫ途径激活血管平滑肌细胞(ＶＳＭＣ)系裂素活化的蛋白激酶或细胞外信号调节激酶 (ＥＲＫ1 /2 )。然而 ,这不能解释ＡｎｇⅡ促进ＶＳＭＣ增生的作用可被ＰＩ3Ｋ的抑制剂Ｗｏｒｔｍａｎｎｉｎ所阻断
Previous studies by the authors showed that angiotensin II activates vascular smooth muscle cells (VSMCs) by the Ras-PKCzeta-MEK pathway, or mitochondria-activated protein kinase or extracellular signal-regulated kinase (ERK1 / 2). However, this does not explain that the effect of Ang II on VSMC proliferation can be blocked by PI3K inhibitor Wortmannin