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目的 :研究大肠肿瘤中bcl- 2、bax基因的蛋白表达和意义。方法 :应用免疫组织化学SP方法检测 136例大肠肿瘤中bcl- 2、bax基因的蛋白表达。结果 :bcl - 2在大肠腺瘤、大肠癌中的阳性表达率分别为 :6 6 7%和 5 4 0 % ,bax为 75 0 %和 6 7 0 %。高分化腺癌和低分化腺癌中bcl- 2、bax的阳性表达率相比较均有显著性差异 (P <0 0 5 )。结论 :bcl - 2、bax的异常表达与大肠肿瘤的发生有关。并与其病理分级密切相关 ,二者可能通过对细胞凋亡的调节而对肿瘤的演进过程产生影响。
Objective: To study the protein expression of bcl-2 and bax in colorectal tumor and its significance. Methods: Immunohistochemical SP method was used to detect the protein expression of bcl-2 and bax in 136 cases of colorectal tumor. Results: The positive rates of bcl - 2 in colorectal adenoma and colorectal cancer were 66.7% and 54.0%, 75.0% and 60.7% respectively. The positive rates of bcl-2 and bax in well differentiated adenocarcinoma and poorly differentiated adenocarcinoma were significantly different (P <0.05). Conclusion: Abnormal expression of bcl - 2 and bax is associated with the development of colorectal cancer. Which is closely related to the pathological grade. Both of them may influence the evolution of the tumor through the regulation of apoptosis.