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为观察胆道疾病患者非维生素Ｋ依赖性凝血因子及血小板功能和抗凝血功能的变化，对３３例胆道疾病患者和２４例健康成人的血小板聚集试验（ＰＡｇＴ）和粘附试验（ＰＡｄＴ）、Ⅷ因子促凝活性（ＦⅧ∶ｃ）、抗凝血酶Ⅲ活性（ＡＴⅢ∶ａ）及其抗原（ＡＴⅢ∶Ａｇ）、血管性假血友病因子（ｖＷＦ）以及纤维蛋白原（Ｆｇ）进行了对比研究。结果显示：ＰＡｇＴ、ＰＡｄＴ、ＡＴⅢ∶ａ和ＡＴⅢ∶Ａｇ各组间无明显差异（Ｐ＞０．０５）；胆道疾病各组Ｆｇ均明显升高（Ｐ＜０．０１）；梗阻性黄疸组ＦⅧ∶ｃ明显高于正常组和无黄疸组（Ｐ＜０．０１）；无黄疸组、良性梗黄组和恶性梗黄组的ｖＷＦ水平依次递增（Ｐ＜０．０１）。由此表明：胆道疾病患者Ｆｇ、ＦⅧ∶ｃ和ｖＷＦ明显升高可能是患者对凝血功能障碍的一种自身保护机能。
To observe the changes of non-vitamin K-dependent coagulation factors, platelet function and anticoagulant function in patients with biliary tract diseases, 33 patients with biliary tract disease and 24 healthy adults with platelet aggregation test (PAgT) and adhesion test (PAdT), Ⅷ (FⅧ: c), antithrombin Ⅲ activity (ATⅢ:a) and its antigen (ATⅢ:Ag), von Willebrand factor (vWF) and fibrinogen (Fg ) Conducted a comparative study. The results showed that there was no significant difference between the groups of PAgT, PAdT, ATⅢ: a and ATⅢ:Ag (P> 0.05); Fg in each group of biliary diseases were significantly increased (P <0.01); Obstruction FⅧ:c in jaundice group was significantly higher than that in normal group and without jaundice group (P <0.01). The vWF levels in non-jaundice group, benign group and malignant group were increased in turn (P <0.01). This shows that: patients with biliary disease Fg, F â ... § and vWF significantly higher may be patients with coagulation disorders as a self-protection function.