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本文报道25名老年重危病人接受丁胺卡那霉素校正剂量治疗的药代动力学和肾毒性,并与观察条件基本一致的25名接受艮他霉素校正剂量治疗的重危病人进行比较。校正剂量是使丁胺卡那霉素高峰血浓达20～40μg/ml,最低值不低于5μg/ml,艮他霉素血浓高峰为4～10μg/ml,最低值不低于2μg/ml,两者剂量比率为3∶1及4∶1,平均给药10天,临床特性两组基本一致,唯丁胺卡那霉素组中19/25例有氨基糖苷类用药史,而艮他霉素组仅9/25例(P<0.01)。艮他霉素组及丁胺卡那霉素组分别有15及10例死亡。所有血、尿、组织内丁胺卡那霉素浓度系采用
This article reports the pharmacokinetic and nephrotoxic effects of 25 doses of amikacin in 25 elderly critically ill patients and compared them to 25 critically ill patients treated with gentamicin supplemented with essentially identical observation conditions . The calibration dose is to make the peak concentration of amikacin reach 20-40μg / ml, the minimum value is not lower than 5μg / ml, the thickness of gentamicin peak is 4-10μg / ml, the minimum is not lower than 2μg / ml, the dose ratio between the two is 3: 1 and 4: 1, the average administration for 10 days, the clinical characteristics of the two groups are basically the same, amylamine kanamycin group 19/25 patients with aminoglycoside drug history, Burgundy In the thalomycin group, only 9/25 patients (P <0.01). There were 15 and 10 deaths in the gentamycin group and amikacin group, respectively. All blood, urine, tissue concentrations of amikacin used