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三、肝细胞内质网在药物代谢中的作用许多脂溶性药物,在体内通过肾小球滤过膜,经扩散作用透过肾小管上皮细胞又重被吸收。为使之迅速排泄,机体必须把这些无极性的脂溶性化合物转变为极性水溶性物质,使之在生理 pH 下易于解离,不与血浆白蛋白及组织蛋白相结合。亦不贮存在脂肪中,并失去透过细胞膜的能力,便于经胆汁或肾脏排泄。大多数情况下这种转化作用可导致药物灭活。某些药物生物转化过程所涉及的酶系统位于肝细胞内质网或其它组织中。如将肝细胞制成匀浆,经过超速离心,可把内质网部分分离出来,称为微粒
Third, the liver cell endoplasmic reticulum in the role of drug metabolism Many fat-soluble drugs, in the body through the glomerular filtration membrane, through the proliferation of renal tubular epithelial cells were reabsorbed. To allow rapid excretion, the body must convert these nonpolar liposoluble compounds to polar, water-soluble substances that are readily dissociated at physiological pH and not bound to plasma albumin and tissue proteins. Not stored in fat, and lose the ability to penetrate the cell membrane, easy to excretion by the bile or kidneys. In most cases this transformation can lead to drug inactivation. Some of the drug biotransformation processes involve the enzyme system in the liver’s endoplasmic reticulum or other tissues. Such as the liver cells made of homogenate, after ultracentrifugation, the endoplasmic reticulum can be part of the separation, known as particles