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[目的]探讨氨氯地平联合应用阿托伐他汀钙对高血压患者颈动脉内膜中层厚度的影响。[方法]将某院2008年12月～2009年6月收治的120例高血压患者随机分为观察组和对照组,每组60例,对照组采用氨氯地平与依那普利联合治疗,观察组采用氨氯地平联合应用阿托伐他汀钙治疗,比较两组患者治疗12个月时的颈总动脉内膜中层厚度(IMT)、斑块面积及血压、血脂水平。[结果]观察组治疗12个月后IMT、斑块面积的减小显著优于对照组,P﹤0.05;观察组血压、血清总胆固醇(TC)、血清低密度脂蛋白(LDL)、血清甘油三酯(TG)水平较治疗前的改善程度显著优于对照组,P﹤0.05。[结论]氨氯地平联合应用阿托伐他汀钙能够显著延缓颈动脉硬化的进程,可以达到稳定与消退斑块的作用。
[Objective] To investigate the effect of combination of amlodipine and atorvastatin on carotid intima-media thickness in patients with essential hypertension. [Methods] A total of 120 hypertensive patients admitted from December 2008 to June 2009 in a hospital were randomly divided into observation group and control group, 60 cases in each group. The control group was treated with combination of amlodipine and enalapril, The observation group was treated with amlodipine combined with atorvastatin calcium, and the common carotid artery intima-media thickness (IMT), plaque area, blood pressure and blood lipid levels were compared between the two groups. [Results] The decrease of IMT and plaque area in observation group was significantly better than that in control group at 12 months after treatment (P <0.05). The blood pressure, serum total cholesterol (TC), serum low density lipoprotein (LDL) The triglyceride (TG) level was significantly better than the control group before treatment (P <0.05). [Conclusion] Amlodipine combined with atorvastatin calcium can significantly delay the process of carotid atherosclerosis, and can stabilize and regress the plaque.