目的:探讨丹参防治肝纤维化的效果和机理。方法:分别采用四氯化碳(CCl_4)及二甲基亚硝胺(DMN)诱导的大鼠肝纤维化模型,以秋水仙碱作对照,观察肝组织病理学,Ⅰ、Ⅲ型胶原免疫组化,检测肝组织Hyp、MDA、SOD及血清肝功能。结果:丹参和秋水仙碱在两种模型实验中皆显示有良好的抗肝纤维化效果。其中丹参有显著的提高肝SOD活性,降低MDA含量的作用。结论:丹参抗脂质过氧化的作用是其抗肝纤维化的重要机理,对胶原代谢也有直接的作用。 Objective: To investigate the effect and mechanism of salvia miltiorrhiza on liver fibrosis. METHODS: Rat hepatic fibrosis models induced by carbon tetrachloride (CCl_4) and dimethylnitrosamine (DMN) were used, and colitis was used as a control to observe the histopathology of the liver. Type I and III collagen immunotherapy groups were used. To detect liver tissue Hyp, MDA, SOD and serum liver function. Results: Salvia miltiorrhiza and colchicine showed good anti-hepatic fibrosis effect in both model experiments. Salvia miltiorrhiza can significantly increase liver SOD activity and reduce MDA content. Conclusion: The anti-lipid peroxidation effect of salvia miltiorrhiza is an important mechanism of anti-hepatic fibrosis, and it also has a direct effect on collagen metabolism.