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孕妇接触环境中的多环芳烃(PAH)已成为目前具有重要生物学意义的一个现实问题。作者综合了下述五点以引起人们对此问题的重视。1.胎儿可通过母体的食物、饮水以及吸入的污染空气(特别是吸烟)长期接触不同水平的PAH。动物实验表明,这些高脂溶性化合物很容易由母体血流穿过胎盘进入胎儿组织,引起肿瘤。2.胎儿组织对于由化学因子(包括 PAH)引起的致癌性转化特别敏感,己稀雌酚穿过胎盘诱发人阴道腺癌的经验证明了此点。3.人类及猴的胎儿组织能促进各种外源化合物(包括 PAH)的羟化作用。PAH 芳香环
The exposure of pregnant women to polycyclic aromatic hydrocarbons (PAH) in the environment has become a practical issue with important biological significance. The author synthesized the following five points to draw people’s attention to this issue. 1. The fetus can be exposed to different levels of PAH through maternal food, drinking water, and inhaled contaminated air (especially smoking). Animal experiments have shown that these high fat-soluble compounds are easily passed from the mother’s bloodstream through the placenta into fetal tissue, causing tumors. 2. The fetal tissue is particularly sensitive to the oncogenic transformation caused by chemical factors including PAH. This has been demonstrated by the experience of ceftestrol eliciting human vaginal adenocarcinoma across the placenta. 3. Human and monkey fetal tissue can promote the hydroxylation of various exogenous compounds including PAH. PAH aromatic rings