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为了解接触环氧丙烷工人的遗传毒理学效应的改变 ,采用外周血淋巴细胞培养的方法检测了 5 0名接触环氧炳烷工人 (其中包装车间 2 0人 ,车间空气PO浓度 12 2 8mg/m3 ;酸化等车间 30人 ,车间空气PO浓度 16 6mg/m3 )和 42人对照者的外周血淋巴细胞姐妹染色单体互换 (SCE)率 ,并对结果进行分析。接触组SCE (5 6 8次 /细胞 )略高于对照组 (5 39次 /细胞 ) ,两组结果有差异 ,P <0 0 5。接触组的包装车间工人SCE (5 81次 /细胞 )与对照组比较 ,差异有显著性 ,P <0 0 1。同时分析了SCE发生率与工人接触PO的工龄、吸烟等因素的关系
In order to understand the changes of the genotoxic effects of exposure to propylene oxide in workers, 50 peripheral blood lymphocyte cultures were tested for exposure to epoxypropane workers (20 in the packaging plant, 12,28 mg / m3; acidification workshop 30, shop air PO concentration 16 6mg / m3) and 42 controls were peripheral blood lymphocyte sister chromatid exchange (SCE) rate, and the results were analyzed. The contact group SCE (568 cells / cell) slightly higher than the control group (399 cells / cell), the two groups were different, P <0 05. In the contact group, there was a significant difference between the SCE (581 cells / cell) and the control group, P <0.01. At the same time, we analyzed the relationship between the incidence of SCE and worker’s length of service, smoking and other factors