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目的采用Meta分析方法对大环内酯类抗生素治疗哮喘急性发作的疗效进行系统评价。方法以“大环内酯类抗生素”和“哮喘”为检索词,检索CNKI、维普资讯和PubMed数据库,并手工检索美国临床肿瘤学会论文集。根据纳入与排除标准筛选文献,提取数据并评价质量,用Review Manager 5.0软件进行Meta分析,同时进行敏感性分析及发表偏倚的评估。结果本研究共纳入文献6篇,经Meta分析,大环内酯类抗生素可明显改善哮喘发作时症状(OR=3.10,95%CI:1.71~5.64),总体效应检验Z=3.71,P=0.000 2。结论大环内酯类抗生素可有效减少哮喘的反复发作。
Objective To evaluate the efficacy of macrolide antibiotics in treating acute exacerbation of asthma by Meta-analysis. Methods Using the terms “macrolide antibiotics” and “asthma” as the search terms, CNKI, VIP and PubMed databases were searched, and the Proceedings of the American Society of Clinical Oncology was searched manually. Data was screened based on inclusion and exclusion criteria, data were extracted and quality assessed. Meta-analysis was performed using Review Manager 5.0 software, along with assessments of sensitivity and publication bias. Results There were 6 articles included in this study. Meta analysis showed that macrolide antibiotics could significantly improve the symptoms of asthma (OR = 3.10, 95% CI: 1.71-5.64). The overall effect test Z = 3.71, P = 0.000 2. Conclusion Macrolide antibiotics can effectively reduce the recurrence of asthma.