多发性骨髓瘤(multiple myeloma,MM)是骨髓浆细胞的恶性疾病,以产生单克隆免疫球蛋白为特征,常伴有骨痛、贫血和肾功能不全。MM占血液系统肿瘤的10%,>60岁老年患者多见[1]。研究结果[2-3]发现,细胞遗传学异常与MM的发生、治疗方案的选择及预后密切相关。本文结合文献分析1例复杂核型MM患者的临床资料,报道如下。 Multiple myeloma (MM), a malignant disease of bone marrow plasma cells, is characterized by the production of monoclonal immunoglobulins, often accompanied by bone pain, anemia and renal insufficiency. MM accounted for 10% of hematological tumors, more than 60 years old elderly patients more common [1]. The findings [2-3] found that cytogenetic abnormalities and the occurrence of MM, treatment options and prognosis are closely related. This article combined with the literature analysis of 1 case of complex karyotype MM clinical data reported as follows.