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目的探讨克罗米芬联合二甲双胍治疗多囊卵巢所致不孕症的临床效果。方法选取2013年3月至2016年3月南阳市第一人民医院收治的多囊卵巢综合征患者100例,随机分为两组,每组50例,观察组给予克罗米芬联合二甲双胍治疗,对照组给予单纯克罗米芬治疗,比较两组空腹胰岛素(FINS)、促卵泡激素(FSH)、空腹血糖(FPG)、促黄体激素(LH)、睾酮(T)等水平的变化,以及两组排卵率、妊娠率、早孕流产率、子宫内膜厚度等。结果两组FSH、LH、FPG、T比较差异显著(P<0.05),两组妊娠率、内膜厚度比较,差异也显著(P<0.05)。结论克罗米芬与二甲双胍联合治疗多囊卵巢综合征所致不孕症患者,能够优化病人体内的激素分泌,增加妊娠成功率,减少并发症,有很好的应用推广价值。
Objective To investigate the clinical effect of clomiphene combined with metformin in the treatment of infertility caused by polycystic ovary. Methods From March 2013 to March 2016, 100 cases of polycystic ovary syndrome patients admitted to First People’s Hospital of Nanyang City were randomly divided into two groups (n = 50 in each group). The observation group was given clomiphene combined with metformin, and the control group The treatment with clomiphene citrate alone was given. The changes of fasting insulin (FINS), follicle stimulating hormone (FSH), fasting blood glucose (FPG), luteinizing hormone (LH) and testosterone (T) Pregnancy rate, abortion rate of early pregnancy, endometrial thickness and so on. Results There were significant differences in FSH, LH, FPG and T between the two groups (P <0.05). There was also significant difference in pregnancy rate and intima thickness between the two groups (P <0.05). Conclusion Clomiphene combined with metformin in patients with infertility caused by polycystic ovary syndrome can optimize hormone secretion in patients with increased success rate of pregnancy and reduce complications, there is a good value to promote the use of.