论文部分内容阅读
1983年9月至1988年4月间80例经组织学或细胞学证实的小细胞型肺癌,用CAV-CCNU方案(环磷酰胺、阿霉素、长春新碱、环己亚硝脲)化疗。其中42例加用局部放疗,9例加用头颅 预防性照射。结果32例获C R,33例获P R,完全缓解率40％,总缓解率81.3％,与文献报告结果相似 全组治疗后中位生存期11个月,局限期与广泛期分别为15个月及10个月。治疗后取得完全缓解者中数生存期16个月,较治疗失败者生存期有所改善。一年生存率38.4％,二年生存率11.3％。治疗不能取得C R或P R者无1例存活1年以上。大部份病例治疗后曾发生白细胞减低及脱发,1例死于严重感染,其余均能耐受。本文材料证明以化学治疗为主的综合治疗对小细胞肺癌病人改善预后确有一定帮助,但长期存活者仍少见。
Eighty cases of small cell lung cancer confirmed by histology or cytology between September 1983 and April 1988 were treated with the CAV-CCNU regimen (cyclophosphamide, doxorubicin, vincristine, and nitrosourea). . Of these, 42 were treated with local radiotherapy and 9 were treated with cranial prophylactic radiation. Results CR was obtained in 32 cases and PR was obtained in 33 cases. The complete remission rate was 40% and the total remission rate was 81.3%. The results were similar to those reported in the literature. The median survival time was 11 months after treatment, and the limitation period and extensive period were 15 months. And 10 months. The median survival time of patients who achieved complete remission after treatment was 16 months, which was better than the survival time of those who failed to treat. The one-year survival rate is 38.4%, and the two-year survival rate is 11.3%. None of the patients who failed to achieve C R or P R survived for more than one year. In most cases, leukopenia and alopecia occurred after treatment. One patient died of severe infection, and the rest were tolerated. This article proves that comprehensive treatment based on chemotherapy can certainly help patients with small cell lung cancer to improve their prognosis, but long-term survivors are still rare.