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一、抗独特型抗体与网络学说众所周知,抗体形成学说经历了一个由侧链模板到克隆选择学说的过程,而网络学说则是近几年来免疫理论上的一项大突破。Jerne在承认Burnet选择学说的基础上,提出了抗体分子的可变区不仅表现为抗体活性,而且也显示抗原性,所以IgG分子既是抗体又是抗原,对Ig可变区表现为抗原特异性的称为独特型。对于能够识别该独特型的另一个Ig分子称为抗独特型抗体。独特型和抗独特型抗体构成了网络学说的物质基础,而抗独特型抗体与刺激产生独特型抗体之抗原间的镜像关系,则是其可能作为内影像疫苗的理论基础(见下图)。
First, anti-idiotypic antibodies and network theory As we all know, the antibody formation theory has gone through a side chain template to clone selection theory of the process, and network theory is immune theory in recent years, a major breakthrough. Based on Burnet’s choice theory, Jerne proposed that the variable region of an antibody molecule not only behaves as an antibody, but also as an antigen, so that the IgG molecule is both an antibody and an antigen, and the Ig variable region appears to be antigen-specific Known as the unique type. Another Ig molecule that recognizes this idiotype is called an anti-idiotypic antibody. The idiosyncrasies and anti-idiotypic antibodies make up the material basis of the network doctrine, and the mirror image of the anti-idiotypic antibody and the antigen that stimulates the production of idiosyncratic antibodies may serve as the rationale for an in-vivo vaccine (see below).