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既往慢性淋巴细胞白血病(慢淋)的染色体研究均采用加植物血凝素(PHA)的外周血淋巴细胞培养。然而大多数慢淋系B细胞性恶性变,而PHA主要作为T细胞激活剂,故除少数报告有14q~+标记的异常外,其余皆为正常核型。近来认识到多克隆B细胞激活剂有刺激慢淋B细胞合成DNA和分泌免疫球蛋白的能力,其中EB病毒(EBV)和脂多醣(LPS)的效力最强。本文报道11例慢淋外周血淋巴细胞加EBV、LPS
Chromosomal studies of chronic lymphocytic leukemia (CLL) have been performed using peripheral blood lymphocytes cultured with phytohemagglutinin (PHA). However, most chronic lymphocytic B-cell malignancies, while PHA is mainly used as a T-cell activator, so except for a few reported abnormalities with the 14q+ mark, the rest are all normal karyotypes. It has recently been recognized that polyclonal B cell activators stimulate the ability of Cry1line B cells to synthesize DNA and secrete immunoglobulins, with Epstein Barr virus (EBV) and lipopolysaccharide (LPS) being the most potent. This article reports 11 cases of chronic lymphocytic peripheral blood lymphocytes plus EBV, LPS