前文报告了青蒿醚的抗疟活性与毒性,动物实验证明,青蒿醚的抗疟活性比青篙素提高6倍,疗效更快而彻底,无明显的毒性。此种结果与临床试用结果基本符合。为了进一步了解青蒿醚的体内过程。为临床合理用药,增强疗效,提供参考。本实验采用同位素示踪法,初步研究了~3H青蒿醚在小鼠体内的吸收、分布、排泄和代谢。 Earlier reports of artemisinin anti-malarial activity and toxicity, animal experiments show that artemether anti-malarial activity than the six times higher than the bromelain, the effect faster and thorough, no significant toxicity. This result is basically in line with clinical trial results. In order to understand more about artesunate in vivo process. For clinical rational use of drugs to enhance efficacy, provide a reference. In this experiment, isotope tracer method was used to study the absorption, distribution, excretion and metabolism of ~ 3H artesunate in mice.