一、前盲 1963年Oudin和Kunkel等首次报告了在人和兔的抗体分子的V区存在有一种独特的抗原特异性,随后,Oudin将其正式命名为Idiotype,即独特型。在以后的十余年中,人们对独特型存在的意义了解甚少,只是认为是Ig分子的一种遗传标志。直到1972年,首次发现了独特型抑制现象,提示抗独特型抗体是一种高度特异、强有力的免疫调节剂。随后又相继证实 First, the former blind In 1963, Oudin and Kunkel, etc. for the first time reported in the human and rabbit antibody V region there is a unique antigen-specific, then, Oudin officially named Idiotype, that is unique. In the next ten years or so, little is known about the existence of idiosyncrasies, but only as a genetic marker of Ig molecules. Until 1972, for the first time found a unique type of inhibition, suggesting that anti-idiotypic antibodies is a highly specific and potent immunomodulator. Then confirmed again